Evaluation of cardioprotective activity of ethanolic leaves extract of Ficus religiosa (Peepal plant) in albino wistar rats using doxorubicin-induced Cardiotoxicity

The current study aims to assess the potential cardioprotective efficacy of Ficus religiosa leaves extract in rats. In this investigation, one rat model of cardiotoxicity caused by doxorubicin (200 mg/kg, S.C.) was used to assess the cardioprotective efficacy of 70% ethanolic leaf extract of Ficus religiosa. Heart weight index (HWI) and biomarkers including ALT, AST, and LDH were considered while determining the cardioprotective property. Animals used in experiments had their hearts subjected to histopathological research as well. Ficus religiosa leaf produced 45% extract and was found to have Flavonoids, Alkaloids, Tannins, Phenols, Saponins, Glycosides, and Carbohydrates as a chemical ingredient. The cardiotoxicity that DOX (doxorubicin) caused in test animals was found to be protected by Ficus religiosa leaf extract. When compared to the group that had cardiotoxicity induced, it was also discovered that the HWI had decreased due to Ficus religiosa leaf extract. Following the estimation of the biomarker enzymes, the histopathology studies were also completed. When tested on albino Wistar rats, it was discovered that the Ficus religiosa leaf extract had considerable cardioprotective action.