Non-Carcinogenic Genotoxic Drugs (NCGDS): A new concept of old drugs with Genotoxic side effects

We first proposed that non-carcinogenic genotoxic drugs (NCGDs) can alter gene expression patterns through affecting 3D genome structure, which makes NCGDs be able to prevent viral infections. The NCGDs exclusively refer to old drugs that are non-carcinogenic but have genotoxic side effects that influence 3D genome structure. Some old drugs that induce expression of many genes, but no obvious genotoxicity is tested out, also belong to NCGDS. In a word, any old drugs with genotoxic side effects that are non-carcinogenic but can alter expression of many genes are named as NCGDs. One feature of NCGDs is cure-all properties, leading them to be able to treat many diseases. In this paper, a mini review on history and function of NCGDs is presented.