DNA replication outside of S Phase in cancer cells could be DNA-to-DNA transcription

Recently, literature search showed that cancer cells often have DNA replication outside of S phase. This DNA replication can occur during G2, M, next G1 phases of the cell cycle, which seems to have missed up the subdivision of standard cell cycle. We don’t believe that there is DNA replication machinery in every phase of the cell cycle. We assume that instead of DNA replication outside of S phase, DNA-to-DNA transcription could be a real thing that was first found in malaria parasite Plasmodium falciparum. Besides, both cancer cells and malaria cells belong to eukaryotic cells and have common feature of uncontrolled cell division; therefore, if there is DNA-to-DNA transcription in malaria cells, the cancer cells should have this function too. DNA-to-DNA transcription might not miss up the subdivision of the cell cycle and might help to resolve various replication stresses encountered in DNA replication during the S phase and preserve the genome integrity.