Cancer is an emerging public health problem in Nepal. The cancer data can be use for effective planning and police formation to control and prevent the disease. This study aims to determine the distribution of cancer incidence in different districts of the nation. This was a descriptive study with primary and secondary data collection in 1st January to 31th December 2019. In the year of 2019, net 4894 new cancers were diagnosed in this Centre. Whereas, 4700 were Nepalese cases. Among the Nepalese cases, Most of the cases were from Chitwan followed by Nawalparasi and Rupendehi. According to available data, 2111 (44.91%) male and 2589 (55.09%) were female. The most frequent form of cancer for both sexes was C34 bronchus & lung 622 (13.23%), followed by C53 cervix uteri 544 (11.57%), and C50 breast 493 (10.48%). The incidence of cancer was seen to be increasing day by day. Well organized awareness activities, HPV vaccination and screening programme was recommended to control and prevent the cancer burden in Nepal.