Post-vaccination encephalitis is an inflammatory disorder of the central nervous system. It is triggered by certain vaccines. The diagnosis of Post-vaccination Encephalitis depends on the close temporal relationship between vaccination and clinical presentation. We describe a 65-year-old female with Post-vaccination Encephalitis following COVISHIELD vaccine who came to a tertiary care centre in South Kerala, India after a few days of administering the same. Encephalitis is a very rare side effect of vaccines. The patient had allegedly suffered from acute encephalopathy, damage or disease that affected the brain after she was administered the vaccine. Was she suffering from direct viral infection of the central nervous system or from the spectrum of para-infectious and prothrombotic processes related to COVID-19? It may not be completely concluded that this patient experienced an adverse effect following immunization of the viral vector vaccine which is in literature not possible, with the provisional diagnosis being aseptic meningitis.