Correlation between estrogen, progesterone receptor, human epidermal growth factor receptor 2 with grade and subtype in early diagnosis of breast cancer

The current study was conducted on 100 individuals at Global Research Labs in Egypt.  Included patients selected from the Ain Shams Internal Medicine hospital, oncology department in the period from March 2018 to March 2019. Patients were diagnosed as Breast Cancer before receiving any treatment in form of Chemotherapy or Radio-therapy. They were diagnosed on the basis of histopathology and radiological picture such as CT scan. The age of the patients ranged from 30 to 75 years. Majority of tumors were predominantly of histopathological grade two. By Immunohistochemistry 77% were ER+/PR+, 40% were Her2/neu positive and 8% were triple negatives. A significant association was seen between histologic grade and hormone receptor status. Microscopic review of 100 consecutive human breast biopsy and mastectomy specimens were correlated with estrogen and progesterone receptor and HER 2 content of the tissue, by subtype and degree of differentiation. Of the 4 grades of differentiation; the less differentiated Grade III tumors showed significantly lower levels of estrogen and progesterone receptors in infiltrating ductal and lobular carcinoma. While grade ll tumors showed significantly higher levels of ER, PR & HER 2 receptors.