Cancer: An abnormal growth of cells which tend to proliferate in an uncontrolled way and, in some cases, to metastasize (spread). which is a major public health problem in the world. This study aims to determined the multi-institutional cancer incidence in Nepal. In this descriptive analysis, data were collected from different co-action hospitals of National Cancer Registry system from January to December 2017, where diagnostic and treatment facilities are available. Most of the cases were reported by BPKMCH 44.08% Followed by BCH 24.99 % and BH 8.20%. The most valid basis of diagnosis was biopsy/histology 36.41% followed by cytology/haematology 30.98% and radiology 14.33%. Cancer cases were most prevalent (13.11%) in age group of (60-64) years for both sex (male:13.97% and female: 12.35%.). Chemotherapy was the first choice of treatment 27.93% followed by surgery alone 17.75%. The most common cancer in Nepal for 2017 was bronchus & lung 12.81 % followed by cervix 8.82% and breast 8.71%. Among males, lung cancer 15.93% was the most frequent followed by stomach 6.56% and bladder 4.88%. Whereas, cervical cancer was a leading cancer site for female 16.64% followed by breast 15.98% and lung 10.04%. Cancer incidence found to be increased yearly in Nepal and thus effective and comprehensive cancer prevention programme should be carried out in national context.