In recent years, the development of wearable health-care technology has gained significant attention, driven by the need for continuous health monitoring and the integration of advanced materials. This paper presents the design and implementation of a soft, biocompatible biosensor system aimed at enhancing the wearable health-care devices. The proposed biosensor system incorporates flexible, skin-conforming materials to ensure comfort and long-term wear ability. By utilizing biocompatible polymers and innovative fabrication techniques, the system can accurately check the health status by monitoring of sweat composition, and biomarkers such as electrolytes, metabolites, and pH levels. The core component of the system is a flexible substrate embedded with microelectronic sensors and wireless communication modules, enabling real-time data acquisition and transmission to external devices for further analysis. Preliminary concept of the sweat-based biosensor system demonstrates high accuracy and reliability under various environmental conditions, making it suitable for diverse applications in personal health monitoring, medical diagnostics, and remote patient care. The integration of this soft, biocompatible sweat-based biosensor system into wearable health-care technology has the potential to revolutionize health data collection and utilization, promoting proactive health management and enhancing overall patient outcomes.