This study aimed to evaluate the efficacy of Moringa oleifera seeds powder on purification White Nile river water, during the dry season (March-April 2014), water samples were collected from twelve different locations from the River at El duwaim city, on dimension 3.0 meters in front of the bank and 20 centimeters below the water surface. The physico-chemical parameters concentrations of water samples (pH, turbidity, electrical conductivity, total dissolved salts, total hardness, alkalinity, iron and chloride) were detected before treatment by Moringa oleifera seeds powder., various doses of Moringa seed powder (50, 100 and 150 mg / L) were added to water samples, and then left it for an hour to two hours, and analyzed to detect the effects on that parameters. The results showed that there was a decrease in the concentration of these parameters is directly proportional with increasing dose and time respectively (except pH).