Mathematics is a pure science subject that is assumed by some students to be a difficult subject. This is influenced by internal and external factors of learners. One of the internal factors is the ability to think creatively and one of the external factors is problem-based learning model. This study aims to see the interactions that occur between the model problem-based learning and the ability to think creatively on mathematics learning outcomes. Quasi-experimental was chosen to be the type of research used in the study with 129 students as subjects. Data were collected from the results of student tests and then tested the hypothesis using a two-way ANOVA test. The results showed that there was an interaction between problem-based learning model and the ability to think creatively on mathematics learning outcomes.