Over one year from April 2023 to March 2024, the main issues contributing to sample errors were identified as lack of staff knowledge, mishandling of samples, inadequate sample volumes, labeling mistakes, inexperience among new staff, and difficulties in collecting samples from challenging veins. Closed-method training, on-the-job reinforcement, and hands-on practice with dummy arms were implemented to address these issues. This study assesses the effectiveness of a focused intervention campaign designed to decrease errors in sample collection in a clinical laboratory, specifically focusing on samples collected by nurses. This study focuses on addressing sample errors in the context of nurse-collected samples within a clinical laboratory setting. Recognizing that nurses are pivotal in the sample collection process, the study aims to identify and address the specific factors contributing to sample errors in this group. By investigating the root causes of these errors and implementing targeted interventions, the goal is to enhance the accuracy and reliability of nurse-collected samples, ultimately improving the overall quality of laboratory testing and patient care. The results showed a significant decrease in sample error rates, with a decline from an average of 1.68, 1.69, and 1.53 errors per 1000 lab tests in the early months of the study to 1.28, 1.23, and 1.13 errors per 1000 lab tests by the end of the study period. This positive trend highlights the effectiveness of the campaign's interventions in improving the accuracy and reliability of nurse-collected samples. The findings emphasize the crucial role of continuous staff education and standardized procedures in enhancing laboratory performance. The study's success in reducing error rates illustrates the broader relevance of such targeted approaches in other areas of clinical practice, aiming to promote a culture of ongoing improvement and high-quality standards in laboratory testing.