The cloistered syndrome (SE) is a rare disease secondary to osmotic demyelination, which occurs clinically in patients with a progressive alteration of their motor capacity, which severely affects the quality of life of this type of patient and in the long term leads to death, due to the total loss of basic functions. In the following review of cases, the usefulness of magnetic resonance imaging (MRI) as a diagnostic method of this pathology is analyzed and a brief comparison of its effectiveness with computed tomography (CT) is made, which in turn constitutes a highly used imaging test in recent years for the diagnosis of it.