Undoubtably, COVID-19 pandemic is causing the global hygiene issue; and is leading to a huge demand for vaccines to solve the problem. Since there are different standards of transportation and storage methods for different vaccines, it is the largest challenge for the existing logistics industry. Also, it is leading a new business environment (both opportunities and challenges) the airfreight. Firstly, there is a new business opportunity for the airfreight industry under the COVID-19 and it can lead to a recovery of the air transport industry and reduce the downturn situation for the industry. Then, there are two challenges that the Air Transport Industry worldwide are facing, capacity issues and global distribution of the vaccine delivery (temperature control). In the process of delivering vaccines, airline companies can develop opportunities in the long term and short-term. In the short term, it can help the airline company have a rise in profit. In the long-term, the new system researched in response to this shipment of vaccines can be used to meet future challenges and to carry out different exchanges and cooperation with other countries in the future through vaccine delivery. For refrigerated container suppliers, the opportunity for them to complete vaccines express has enhanced the technology in upgrading the design of containers and gaining revenue. The challenge for them is the cost is high as they need to spend a lot of money to improve the system. Although there are challenges, the improved technology can be used to transfer other medical equipment in the future. In this study, several opportunities and challenges for different parties such as the air transport industry, airline industry and refrigerated container suppliers are discussed. Moreover, it has also discussed the impact of the air cargo business after the shipment of vaccines. For example, decrease the downturn situation of the air transport industry, encourage cooperation between different countries and improve technology on container development and temperature control.