Cancer is a large group of diseases that can start in almost any organ or tissue of the body when abnormal cells grow uncontrollably, go beyond their usual boundaries to invade adjoining parts of the body and/or spread to other organs. The latter process is called metastasizing and is a major cause of death from cancer. A neoplasm and malignant tumor are other common names for cancer. It is an emerging public health problem in Nepal. The trend of cancer incidence is useful for effective planning and police formation to control and prevent the disease. This study aims to determine population based cancer incidence in Nepal for 2016 by using the data from different data sourse of institution of 15 districts of three geographical region i.e. Tarai, Pahad/Hill and Himalaya/Mountain of Nepal. This was a descriptive study with primary and secondary data collection from different data source institution of population based cancer registry programme, since 1st January to 31th December 2016. The mean age at diagnosis in 2016 was 53 yrs. Cancer of bronchus & lung C34 was the common topography followed by cervix uteri C53 and breast C50.The trend of cancer was seen to be increasing day by day. Well organized awareness activities, HPV vaccination and screening programme was recommended to control and prevent the cancer burden in Nepal.