This paper aims to investigate and analyze the role that play monetary policies and prudential measures on mortgage portfolio. It also compares the level of applicability of monetary policies and prudential measures on mortgage portfolio in the low incomes countries of the Economic Community of the Great Lakes Region of Africa (Tanzania, Uganda and Kenya).Panel data analysis was applied to samples from a period of 1990 to 2020 to perform various statistical analyzes and test hypotheses. In spite of that the study investigated the role of prudential measure and monetary policy on loan mortgage in the low income countries rather than high incomes countries as usually, the study added to the existing models new variables suchpolitical instability, financial inclusion, lack of insurance credits, institutional quality and business environment.