Recently, soft bioelectronics have introduced innovative functionalities across various device applications. The use of conventional rigid metal/semiconductor materials in wearable biosensor applications often leads to limited biocompatibility, mechanical mismatch, and chronic tissue damage in biotic/abiotic interfaces. In term of these requirements, alternative materials that offer softness, flexibility, and self-healing capabilities to improve the performance and wearing-comfort on skin. The emergence of soft and self-healing biosensor platforms marks a significant advancement in wearable healthcare monitoring. These platforms integrate novel materials offering flexibility, resilience, and autonomous repair capabilities, thereby addressing key challenges in long-term health monitoring. This paper presents an overview of the development and applications of such biosensor platforms, highlighting their potential to revolutionize healthcare monitoring. The integration of soft and self-healing materials enables comfortable and reliable monitoring, facilitating continuous data collection without compromising user comfort or sensor functionality. This review paper encapsulates the essence of the innovative biosensor platform, emphasizing its transformative potential in wearable healthcare monitoring.