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Submission last date: 15th December 2024

Thermogenesis and the membrane redoxy potential three state dependent 9 stepped full cycle of proton conductance in the human body

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Author: 
Ambaga, M., Tumen-Ulzii, A. and Buyantushig, T.
Page No: 
796-799

The influx of H+ into the matrix of the mitochondrion and bypasses the ATP synthase channel, uncouples oxidative phosphorylation, and the energy from the proton motive force is dissipated as heat rather than producing ATP from ADP, all these processes have been conducted under influence of increase of unsaturated fatty acids –alpha state as first variant of basic three membrane states of a membrane - redox potentials three - state (MRPTS ) within amembrane - redox potentials three - state line system reaction medium firstly described by us, which have been functioned in the framework of  “Donators + membrane - redox potentials three - state line system + O2 + АDP + Pi + H+ + nH+membrane space = (ATP + heat energy) + H2O + nH+matrix + CO2” which is belong to the the membrane redoxy potential three state dependent 9 stepped full cycle of proton conductance. The mitochondria in a eukaryotic cell utilize fuels to produce energy in the form of adenosine triphosphate (ATP), this process involves storing energy as a proton gradient, also known as the proton motive force (PMF), across the mitochondrial inner membrane, this energy is used to synthesize ATP when the protons flow across the membrane through the ATP synthase enzyme is known as chemiosmosis, in endotherms, body heat is maintained by signaling the mitochondria to allow protons to run back along the gradient without producing ATP (proton leak), owing to increase in unsaturated fatty acids – alpha state as first variant of basic three membrane states of a membrane - redox potentials three - state (MRPTS) system within a membrane - redox potentials three - state line system reaction medium firstly described by us. Uncoupling protein in the inner membrane, facilitates the return of the protons after they have been actively pumped out of the mitochondria by the electron transport chain, this alternative route for protons uncouples oxidative phosphorylation and the energy is released as heat , owing to increase in unsaturated fatty acids – alpha state as first variant of basic three membrane states of a membrane - redox potentials three – state system (MRPTS ) within amembrane - redox potentials three - state line system reaction medium firstly described by us. Brown adipose tissue or brown fat makes up the adipose organ together with white adipose tissue - beige, are metabolically active in adult humans, produces heat by non-shivering thermogenesis, is crucial for maintaining core body temperature and energy balance, contains more capillaries than white fat, these supply the tissue with oxygen and nutrients and distribute the produced heat throughout the body, all these processes have been conducted under influence of  increase of unsaturated fatty acids – alpha state as first variant of basic three membrane states of a membrane - redox potentials three - state system (MRPTS) within amembrane - redox potentials three - state line system reaction medium firstly described by us.

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