A detailed study was carried out on biomolecules and economic attributes using multiple regression analysis to investigate their relationship in the silkworm, Bombyx mori. The activity of protein, carbohydrate, amylase, acetylcholinesterase and peroxidase in the haemolymph was estimated. The commercial characters viz., larval-duration, mortality, weight, cocoon weight, shell weight, shell ratio, pupal weight, fecundity, deformed moths, survival at spinning were selected. The results of quantitative analysis were subjected for statistical analysis against selected commercial characters to know the level of correlation between them. The results of statistical analysis clearly showed that protein, carbohydrate and amylase has highly positive correlation with selected commercial characters except larval mortality and deformed moths. In contrast, the peroxidase indicated highly positive correlation with larval mortality and deformed moths only. The acetylcholinesterase has exhibited a different trend on different days.