Adrenal involvement without lymph nodes infiltration secondary to cutaneous T-cell lymphoma is very rare. Large anaplastic T cell lymphoma originating from the skin and metastasizing to bilateral adrenal glands are uncommon occurrence without similar cases founded in the review of the literature. We present a case of a 67 year-old African man who presented with skin lesion diagnosed as large anaplastic T cell lymphoma metastasized to bilateral adrenal glands. Hormonal analysis didn’t found adrenal insufficiency however, endogenous hypercorticism was observed. The patient was treated by chemotherapy. Prognosis was considered as poor.