Correlation between liver and kidney functions with C-reactive protein in covid-19 patients: An observational study

Coronavirus disease outbreak was caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).  Numerous studies have shown impact of this virus spread on liver and kidney.  In the present study we aimed to evaluate the correlation of C-reactive protein with liver and kidney biochemical marker levels. Laboratory results were obtained from 40 patients with confirmed RT-PCR positive for SARS-CoV-2, who were admitted in the hospital from 14 May, 2021 to 30 June, 2021. Liver function tests, kidney function tests and C-reactive protein were included to explain the relationship among them in COVID-19 patients. The liver and/or kidney biochemical parameters being analyzed were unevenly distributed among patients with parameters either increased other decreased in comparison to normal reference range. Interestingly, we observed significant positive correlation between C-reactive protein (CRP) levels and SGOT (Aspartate Aminotransferase), alkaline phosphatase, urea and creatinine. Furthermore, other markers such as total protein and albumin were found to be negatively correlated with CRP levels in the serum of COVID-19 patients. The study demonstrated aberrant levels of various parameters for liver and / or kidney function and showed association with CRP. Therefore, measurement of these parameters might assist in monitoring the detrimental effects of SARS-CoV-2 infection on multiple organs.