Introduction: This study assessed amputees’ residual limb stump in the post war era of Acholi sub-region for suitability of prosthetic fit use and associated challenges with their current prosthesis and psycho-socio emotional experiences. Methods: A cross-sectional clinical assessment of amputees living within the communities in Acholi sub-region was done between September 2018 to August 2019 by a team of Surgical Consultants, orthopaedic technician and prosthetic therapist. Result: The biggest proportion of amputees living in the Acholi communities were adults of 35-65yrs (mean of 43.36yrs, SD+/- 15.694) and more male were affected than females (73.4%:26.6% respectively). The negative predictors of prosthetic fit and use were advancing age, gender, increased duration of disability, high percentage of disability, but stump length and power were positive predictor. Lower limb amputees tend to suffer more psycho-socio emotional disorder like pain sensation, stress, mood and anxiety disorders, as well as sexual discrimination. Lower limb amputee experiences more prosthesis complication like excessive sweating, extremely bothersome sound, terrible fit,and terrible appearance than upper limb. Conclusion: Residual stump length and power are the most important predictor of prosthesis fit. For proper prosthetic adherence, mental health and socio-emotional support need to be included in a comprehensive rehabilitation of amputees