Rapid point-of-care diagnostic approach to Covid-19: Electrochemical immunosensor

The rapid spread of corona virus all over the world taught that there is an always requirement for the development of health care services. In that, development in disease diagnosis is so important for any disease to identify the same. For COVID-19, there are RT-PCR test and Rapid antigen Test which is either costly, time consuming or less effective. So, there was a real need for something which can actually help to overcome these loop holes. The electrochemical immune-sensors technology has given a hike by detecting the disease biomarkers by antigen-antibody stable complex formation, which is then converted to electric signal via transducer mechanism. The electrochemical assays are being developed to detect spiked glycoprotein, nucleo-capsid protein, N or S genes, S-RBD protein, Subunit 1-IgG, C-reactive protein, ORF1abRNA, SARS-CoV-2 monoclonal antibodies from the clinical samples of COVID patients. Use of different nano-materials such as Titanium Oxide (TiO2) nanotubes, Graphene Oxide nano-composite has been identified to increase the performance and reducing the limit of detection. Thus the utilization of electrochemical immuno-sensor technology is new hope of ray in the ongoing crisis of the world.