Association between c-reactive protein level and mortality among traumatic cerebral hemorrhagic contusion Sudanese patients, Khartoum, Sudan

C-reactive protein (CRP) has previously found to be a predictive biological inflammatory biomarker of secondary pathologies associated with Traumatic brain injury (TBI). The aim is to determine an association between CRP level with the mortality of traumatic cerebral hemorrhagic contusion patients. A case-control study was conducted on ninety Sudanese patients presented with traumatic cerebral hemorrhagic contusion at the National Center for Neurological Sciences (NCNS) Khartoum-Sudan. Non-Sudanese patients, and hemorrhagic contusion associated with other types of brain bleeding were excluded. Moreover, 90 individuals were selected as controls. The results showed that 95.6% of the patients presented with abnormal CRP level > 6 mg/L (P. value = 0.000). Patients with TBI are at a risk of 70.6 times of having high CRP compared to a healthy control.  Almost 90 % of patients admitted with severe injury (GCS <8) had CRP level > 60 mg/L and 58.3% of the patients with multiple contusions showed CRP level > 60 mg/L compared to 35.5% of patient with a single cerebral contusion. Presence of brain edema was not associated with high levels of CRP. Fifty-nine percent of patients admitted 2 days after trauma have significantly (P. Value <0.05) high CRP levels (> 60 mg/L) compared to 40.0% and 25.6% admitted 1 and 3 days respectively. The number of deaths were 8 (8.9%). Almost 87.5% of them (n=7) had CRP > 60 mg/L. CRP can be considered as an important inflammatory biomarker predictor for morbidity and mortality among traumatic cerebral hemorrhagic contusion.