The wearable electronics as emerging technology has paved the way for the development of on-skin, wearable healthcare monitoring systems. These systems leverage multi-functional sensors to provide real-time monitoring and analysis of various health parameters. The integration of various devices, ranging from mechanical sensor, vibrational sensor to temperature sensor, into wearable platform allows for continuous and non-invasive health monitoring, offering numerous benefits in terms of convenience, early detection of health issues, and personalized healthcare. Here, we review an overview of on-skin, wearable healthcare monitoring systems enabled by multi-functional sensors. We discuss the widely used sensor components for health-care monitoring system, including strain-gauge, electrocardiogram (ECG), vibrational sensor and temperature sensor. With data processing of signals obtained from these sensors, we could monitor the current status of health more accurately. Furthermore, we explore the potential applications of these systems in healthcare, highlighting their use in monitoring vital signs, tracking physical activity, and assessing skin health.