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Submission last date: 15th November 2024

Advances in understanding the interplay between mutagenesis and dna repair: Implications for genomic stability and evolution

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Author: 
Abdulsalam, M., Amina, A. A., Ummulkhair, A. Y. and Zainab, H. F.
Page No: 
6428-6438

This study aims to improve the understanding of the polychromatic relationship between mutagenesis and DNA repair, which is essential for maintaining genomic stability and driving evolution. These biological processes influence genetic diversity, adaptation, and disease development. However, significant research gaps exist, especially concerning how these processes function in non-model organisms and respond to environmental factors. This research aims to address these gaps by investigating how non-model organisms handle mutagenesis and DNA repair, as well as the impacts of environmental factors on these processes. This study has broad implications across biology, medicine, environmental science, and biotechnology. The findings emphasize that mutagenesis occasions play a substantial role in enhancing genetic diversity and facilitating adaptation in non-model species. Simultaneously, DNA repair systems act as vigilant guardians of genomic integrity and genetic stability. Our discoveries shed light on the dynamic interplay between mutagenesis and repair mechanisms, particularly in response to specific changes. Building on these insights, we advocate for further exploration of non-coding DNA's involvement, the complexities of spatiotemporal dynamics in DNA repair, and the impact of epigenetic modifications on mutagenesis and repair processes. More so, this study highlights potential applications in precision medicine, gene therapy, antimicrobial drug development, and environmental bioremediation. In essence, it unravels the intricate interplay between mutagenesis and DNA repair mechanisms, enriching our understanding of fundamental biological processes and their implications for genomic stability, adaptability, and disease. As we delve deeper into these processes, their potential applications in fields such as science, medicine, and environmental solutions become increasingly apparent.

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