Background: Schizophrenia is a severe mental condition where, quality of life is severely impaired in patients with schizophrenia. Noncompliance can affect quality of life by causing psychotic exacerbations. Objectives: To find out quality of life among patient with schizophrenia. To find out correlation between quality of life among schizophrenic patient with socio-demographic variables. Materials and Method: A descriptive cross-sectional study design was adopted for the study. Sample size was 422 and purposive sampling technique was used to select the sample. Data was collected by face to face interview during March, April, May 2023. Questionnaire related to Socio-demographic information, Standard valid tool The Schizophrenia Quality of Life Questionnaire (SQoL-18) was adopted to assess quality of life among schizophrenia. Data were analyzed using descriptive and inferential statistics with SPSS version 20. Results: The mean age of the respondents was 41.02 and standard deviation 12.77. More than half52 (12.3%) of respondents were taking antipsychotics from more than 15 years. Majority of respondents 342 (81.0%) were using atypical antipsychotic. Higher mean score of Schizophrenia quality of life found in family relation (RFa) dimension mean=75.23, lowest was found on Relationship with Friends (RFr) mean=61.37.while comparison of mean score of all eight dimension of (S-QoL-18 Dimension) with adherence level. There is significance mean difference found p=<0.001 from nonadherent group to moderate adherent and adherent group and from moderate adherent to adherent group. Conclusion: Non- adherence was found important factor low Quality of life among schizophrenia patient. Additional factors that were found to be linked included education level, length of sickness, and history of substance use. Implementation of community mental health program may reduce treatment group and decrease non-adherence. Furthermore, it is essential to improve adherence on antipsychotic for better quality of life among schizophrenia patient