In this paper, we present an approach integrating fuzzy logic strategy for solving an optimal control problem of hypoxemic hypoxia tissue blood dioxide carbon exchange in human body. The response to exercise is high- lighted by existence of heart rate and alveolar ventilation which are controls of cardiovascular-respiratory system. In order to verify the adequacy of fuzzy logic strategy, numerical results for a 30 years old woman performing jogging are compared with ones obtained direct method. The findings are in good agreement with empirical data. Therefore approach integrating the fuzzy logic strategy is very important for solving optimal control problem and it induces the performance of cardiovascular-respiratory system.