The aim of this mini-literature review was to describe the traditional use, phytochemistry and biological properties of M. morindoides, a plant used as a conventional African medicine. In this investigation, the literature revealed that M. morindoides extracts were very efficient in the treatment of several diseases including malaria. According to our research, no studies have been conducted on the antisickling properties of Morinda morindoides. Further research is needed to assessment Antisickling activity of the different extracts of the parts of Morinda morindoides.